Name: Felix Aurel Mic

Birth date: april 15-th 1970, Romania

Home address: 2 Dinu Lipatti St., Timisoara, Romania

Marital status: married with three children

Workplace: “Victor Babeș” University of Medicine and Pharmacy, Timisoara, Romania


Education

    -1995, graduated as medical doctor from „Victor Babes” University of Medicine and Pharmacy Timisoara, Romania;

    - july 1996 – december 1996 research assistant in the Laboratory of Embryology and Teratology, Institute of Public Health Timisoara;

    - january 1997 – july 1998, research fellowship at the Department of Biochemistry and Molecular Biology, University of Medicine Debrecen, Hungary,
    under the supervision of Prof. Fesus Laszlo. The theme was about identifying new factors involved in thymocytes apoptosis in vivo;

    - august 1998 – november 1999 research assistant Institute of Public Health Timisoara;

    - november 1999 – may 2003 postdoctoral associate at The Burnham Institute, La Jolla, California, USA, in the laboratory of Dr. Gregg Duester, in the Oncodevelopmental Biology Program.
    The subject was studying the role of retinoids in developmental biology in mice by knocking out several genes involved in retinoid synthesis;

    - 2005 - 2012 – researcher at the Center of Immunophysiology and Biotechonology, County Clinical Hospital Timisoara;

    - 2012 – 2016, principal investigator at “Victor Babeș” University of Medicine and Pharmacy, Timisoara, where I run my current project – PN-II-ID-PCE-2011-3-0571 – due to complete at the end of 2016;


PhD thesis

  • on february 13-th 2004 I defended my PhD thesis with the title "Cell Death as a Factor Involved in Normo- and Teratogenesis: Experimental Contributions.

    The Impact of Eicosanoids on the Cell Death in Thymus and Role of Retinoids in Normo- and Teratogenesis in Mouse Embryo". PhD awarded with the diploma no. 4450/02.08.2004.


Courses and training

  • Summer School in Immunology, Timisoara, Romania, 1992.

  • Summer School 'Advanced Techniques in Molecular Biology', Sibiu, Romania, 1994.

  • Summer School 'Biomembranes and diseases', Cluj-Napoca, Romania, 1995.

  • The EMBO Practical Course "Signal Transduction and Cell Surface Structure", Department of Biochemistry and Molecular Biology, University of Medicine Debrecen, Hungary, 1995.

  • The EMBO Practical Course "Physical Analysis of Cell Surface Receptors", University of Medicine Debrecen, Hungary, july 1998.

  • The FEBS Advanced Course on "Membrane Receptors and Transporters" University of Medicine Debrecen, Hungary, august 1998.


Main publications

1. Acetaminophen-induced liver injury: Implications for temporal homeostasis of lipid metabolism and eicosanoid signaling pathway.

Suciu M, Gruia AT, Nica DV, Azghadi SM, Mic AA, Mic FA. Chem Biol Interact. 2015 Dec 5;242:335-44. doi: 10.1016/j.cbi.2015.10.019.


2. Mesenchymal Stromal Cells Differentiating to Adipocytes Accumulate Autophagic Vesicles Instead of Functional Lipid Droplets.

Gruia AT, Suciu M, Barbu-Tudoran L, Azghadi SM, Cristea MI, Nica DV, Vaduva A, Muntean D, Mic AA, Mic FA. J Cell Physiol. 2015 Sep 1. doi: 10.1002/jcp.25177.


3. Insights into the mechanisms of thymus involution and regeneration by modeling the glucocorticoid-induced perturbation of thymocyte populations dynamics.

Moleriu RD, Zaharie D, Moatar-Moleriu LC, Gruia AT, Mic AA, Mic FA. J Theor Biol. 2014 May 7;348:80-99. doi: 10.1016/j.jtbi.2014.01.020.


4. Accumulation of tissue macrophages and depletion of resident macrophages in the diabetic thymus in response to hyperglycemia-induced thymocyte apoptosis.

Barbu-Tudoran L, Gavriliuc OI, Paunescu V, Mic FA. J Diabetes Complications. 2013 Mar-Apr;27(2):114-22. Doi: 10.1016/j.jdiacomp.2012.10.007.


5. Adipocytes differentiated in vitro from rat mesenchymal stem cells lack essential free fatty acids compared to adult adipocytes. Bojin FM, Gruia AT, Cristea MI, Ordodi VL, Paunescu V, Mic FA.

Stem Cells Dev. 2012 Mar 1;21(4):507-12. doi: 10.1089/scd.2011.0491.


6. Arachidonic acid accumulates in the stromal macrophages during thymus involution in diabetes.

Gruia AT, Barbu-Tudoran L, Mic AA, Ordodi VL, Paunescu V, Mic FA. Histochem Cell Biol. 2011 Jul;136(1):79-92. doi: 10.1007/s00418-011-0820-4.


7. Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning. Zhao X, Sirbu IO, Mic FA, Molotkova N, Molotkov A, Kumar S, Duester G.

Curr Biol. 2009 Jun 23;19(12):1050-7. doi: 10.1016/j.cub.2009.04.059.


8. Optimal access to the rat heart by transverse bilateral thoracotomy with double ligature of the internal thoracic arteries.

Ordodi VL, Paunescu V, Mic FA. J Am Assoc Lab Anim Sci. 2008 Sep;47(5):44-6.


9. Artificial device for extracorporeal blood oxygenation in rats.

Ordodi VL, Paunescu V, Ionac M, Sandesc D, Mic AA, Tatu CA, Mic FA. Artif Organs. 2008 Jan;32(1):66-70. doi: 10.1111/j.1525-1594.2007.00461.x.


10. Indomethacin inhibits thymic involution in mice with streptozotocin-induced diabetes.

Mic AA, Mic FA, Tatu CA, Ionac M, Ordodi VL, Paunescu V. Comp Med. 2007 Oct;57(5):476-81.


11. A pressure-controlled rat ventilator with electronically preset respirations.

Ordodi VL, Paunescu V, Mic AA, Gabor L, Ionac M, Toma O, Sandesc D, Mic FA. Artif Organs. 2006 Dec;30(12):965-8.


12. Improved electrodes for electrical defibrillation of rats.

Ordodi VL, Paunescu V, Mischie S, Ignea A, Toma O, Ionac M, Mic AA, Sandesc D, Mic FA. J Am Assoc Lab Anim Sci. 2006 Nov;45(6):54-7.


13. A small scale oxygenator for cardiopulmonary bypass in rats.

Ordodi VL, Paunescu V, Mic AA, Ionac M, Sandesc D, Mic FA. Int J Artif Organs. 2006 Aug;29(8):750-5.


14. Bone marrow aspiration from rats: a minimally invasive procedure.

Ordodi VL, Mic FA, Mic AA, Tanasie G, Ionac M, Sandesc D, Paunescu V. Lab Anim (NY). 2006 May;35(5):41-4.


15. A simple device for intubation of rats.

Ordodi VL, Mic FA, Mic AA, Sandesc D, Paunescu V. Lab Anim (NY). 2005 Sep;34(8):37-9.


16. Raldh2 expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formation.

Mic FA, Molotkov A, Molotkova N, Duester G. Dev Dyn. 2004 Oct;231(2):270-7.


17. Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation.

Mic FA, Sirbu IO, Duester G. J Biol Chem. 2004 Jun 18;279(25):26698-706. Epub 2004 Apr 6.


18. Patterning of forelimb bud myogenic precursor cells requires retinoic acid signaling initiated by Raldh2.

Mic FA, Duester G. Dev Biol. 2003 Dec 1;264(1):191-201.


19. Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis.

Mic FA, Molotkov A, Benbrook DM, Duester G. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7135-40.


20. Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid.

Duester G, Mic FA, Molotkov A. Chem Biol Interact. 2003 Feb 1;143-144:201-10. Review.


21. Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice.

Mic FA, Haselbeck RJ, Cuenca AE, Duester G. Development. 2002 May;129(9):2271-82.


22. RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development.

Mic FA, Molotkov A, Fan X, Cuenca AE, Duester G. Mech Dev. 2000 Oct;97(1-2):227-30.


23. Clearance of apoptotic thymocytes is decreased by inhibitors of eicosanoid synthesis.

Mic FA, Molnar P, Kresztes T, Szegezdi E, Fesus L. Cell Death Differ. 1999 Jul;6(7):593-5.